Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of .. Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell. The cause of vaso-occlusive crisis (VOC) is believed to be ischemic and cold can precipitate crises. . what has worked in previous crises. One study from Oman reported periorbital swelling during vaso-occlusive crises in five patients The patients ranged in age from 6 to 15 years old. Four of.

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SS-RBCs are prone to adhere Sickle hemoglobin can cause damage to the RBC membrane from deformation by polymer formation, In addition, the mutated globin can undergo autooxidation and precipitate on the inner surface of the RBC membrane, causing membrane damage via iron-mediated generation of oxidants.

Continue reading from March 1, Previous: This can rapidly result in death. For these reasons, parenterally administered morphine should be considered the treatment of choice for moderate to severe pain in vaso-occlusive crises. Clev Clin J Med. Management of sickle pain. You can move this window by clicking on the headline.

They should be counseled to wear warm clothes in cold weather, drink adequate amounts of fluids in hot weather and avoid exercising to the point of fatigue and dehydration Table 2. The publication costs of this article were defrayed in part by page charge payment. Many important scientific and clinical contributions in SCD are beyond the scope of this report.


Management of pain in sickle cell disease. Exchange transfusions should be considered only in patients who have a prolonged refractory vaso-occlusive crisis with a stable baseline hemoglobin concentration. Other adhesive interactions require a vasso bridge molecule eg, thrombospondin, VWF.

Approach to the Vaso-occlusive Crisis in Adults with Sickle Cell Disease

Oxygen therapy is often used xrise in the management of vaso-occlusive crises, despite lack of evidence supporting the effectiveness of these measures in all patients. When a vaso-occlusive crisis lasts longer than seven days, it is important to search for other causes of bone pain, such as osteomyelitis, avascular necrosis and compression deformities. Sickle cell anemia with few painful crises is characterized by decreased red cell deformability and increased number of dense cells.

Large fluid volumes may decrease plasma oncotic pressure and increase hydrostatic pressure. E-selectin—mediated vas activates Src kinases, which then leads to the up-regulation of the leukocyte integrin Mac-1 at the leading edge of crawling neutrophils. See related patient information handout on practical tips for preventing a sickle cell crisiswritten by the authors of this article. Management of sickle cell disease. Activating and crose arms of neutrophil activation.

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

Access to the full text of this article requires a subscription. Expert Rev Mol Med. Chronic pain occurs oclusive of the destruction of bones, joints and visceral organs as a result of recurrent crises. Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease.


Available in liquid or tablet form, alone or in combination with acetaminophen. Hydroxyurea has multiple mechanisms by which it produces its clinical response. Vaso-occlusive crisis A vaso-occlusive crisis is a common painful complication of sickle cell anemia in adolescents and adults.

Pediatr Clin North Am. Bottom The drawings are used to evaluate the spatial distribution of pain. Mousa SA, Johansen K.

This approach reduces overmedication and excessive sedation. Targeting adhesion As briefly mentioned above, GMI is a pan-selectin antagonist currently under investigation in clinical trials. From Wikipedia, the free encyclopedia.

Therefore, at any given PaO 2less oxygen is in the deoxygenated state, which is the form most susceptible to polymerization. Optimal management requires a multidisciplinary team that includes a family physician, a hematologist, nurses, a psychiatrist, a physical therapist, a pain specialist and social workers. Ballas SK Complications of sickle cell anemia in adults: The long-term effects of hydroxyurea maintenance therapy are not well known.

Vaso-occlusive crisis – Wikipedia

Ballas SK, Delengowski A. Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell disease.

Consider hospital discharge when the patient’s pain is controlled with an orally administered analgesic or no analgesia is needed. Techniques for determining the severity of pain and its location.

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